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10 Popular Weight Loss Supplements and Pills

The basics of weight loss are to eat less and move more. However, weight loss Supplements and pills can help some people, but you still need to concentrate on a proper diet and exercise.

Remember, weight loss is all about lifestyle changes, and there is no magical pill to help you lose pounds without hard work.

People who depend on supplements alone may harm themselves.

What are Weight Loss Supplements?

Weight loss dietary supplements are available over the counter in a variety of forms, including capsules, tablets, liquids, and powders.

It can include hundreds of ingredients. However, there is no definite evidence that these supplements are effective.

Some people even think that studies conducted on these products were for commercial purposes.

The FDA restricts the use of medicinal substances in dietary supplements because they may interact with other medications and cause hazardous health concerns.

Similarly, a weight-loss diet plan that works for one person will not work for everyone. This applies to supplements as well.

People who are thinking about using supplements for weight management purposes should talk to their doctor about the potential benefits and risks (1).

Here are 10 popular weight loss supplements and pills.

1. Green tea extract

Green tea extract is a popular ingredient in many weight-loss supplements.

The main antioxidant in green tea is EGCG (epigallocatechin gallate). This antioxidant has fat-burning effects.

In addition, green tea extract may increase the activity of norepinephrine.

Many studies have shown that green tea extract can lead to increased fat burning, specifically in the abdominal area.

However, drinking green tea should also have all the health benefits of green tea extracts (2).

2. Caffeine

Caffeine is the psychoactive substance most commonly used for energy-boosting purposes.

According to one study, caffeine can increase metabolism by up to 11% and burn fat by up to 29%. Some studies have also shown that caffeine can cause moderate weight loss.

However, you don’t need to take caffeine in pill form. Coffee and green tea are the best antioxidants and the best sources of caffeine (3).

3. Hydroxy cut pills

Hydroxycut is among the most popular weight loss supplements in the world, and it has been around for more than a decade.

This product has several ingredients, including lady’s mantle extract (Alchemilla vulgaris), wild olive extract (Olea europaea), cumin extract (Cuminum cyminum), wild mint extract (Mentha longifolia), and green coffee bean extract (Coffea canephora).

These extracts may help with weight loss. In one controlled study, the researchers used the same extracts in tablet form on heavy people.

The extracts helped them lose 21 pounds within 3 months.

However, this weight loss supplement might not be suitable for people who are sensitive to caffeine.

4. Garcinia cambogia extract

Garcinia cambogia is also a famous weight-loss dietary supplement. It’s a small green fruit that contains hydroxycitric acid (HCA).

This is the active ingredient in garcinia cambogia, which is sold as a dietary supplement.

Animal studies have shown that it can block a fat-producing enzyme in the body and increase the level of serotonin, which can lead to appetite reduction.

One study involving 130 people compared garcinia to a dummy pill. The weight or body fat percentage between groups was unchanged.

In another study, Garcinia Cambogia caused a weight loss of 2 pounds (0.88 kilograms) over several weeks.

The effects of Garcinia Cambogia on weight loss may not look much, but it may help increase the level of serotonin in the brain, which regulates mood, happiness, and anxiety (4, 5, 6).

5. Orlistat (Alli) by Xenical

Orlistat is a pharmaceutical medicine, marketed under the name Alli, and prescribed under the name Xenical. This weight-loss pill is effective, and it prevents the fat from digestion.

According to Mayo Clinic staff, orlistat helps you lose weight by reducing the amount of dietary fat absorbed in your intestines.

Lipase, a digestive enzyme, aids in the breakdown of dietary fat into smaller components that are stored and later used as energy.

Orlistat blocks lipase activity, and 25% of the fat you eat is removed through bowel movements.

In one study, orlistat in combination with lifestyle changes showed a slight reduction in blood pressure and prevented type 2 diabetes by 37% (7).

Many users have noticed some of the side effects of orlistat, such as urgent bowel movements, oily stools, frequent bowel movements, abdominal pain, and oily spotting on underwear.

A low-fat diet is important to minimize the side effects of orlistat. It is appealing to understand that a low-carb diet is equally effective as a combination of both orlistat and a low-fat diet.

6. Green coffee bean extract

In green coffee beans, the amount of chlorogenic acid is higher than in black coffee beans. because the beans are not roasted yet.

The chlorogenic acid in green coffee can help in burning body fat and regulate blood pressure by slowing down the carbohydrate breakdown in the stomach.

Green coffee extract can also influence how the body manages blood sugar and metabolism. In one study, the group taking the green coffee extract lost 5.4 pounds more than the group taking a dummy pill.

It is high in antioxidants. However, green coffee extracts contain caffeine. Side effects such as diarrhea noticed in certain people allergic to caffeine (8).

7. Glucomannan dietary fiber

Glucomannan, also called konjac, is a dietary fiber extracted from the roots of an elephant foot yam.

The fiber can reduce the absorption of sugar and cholesterol in the intestine, which can help regulate blood sugar levels in diabetics.

It can also lower cholesterol levels, feed friendly intestinal bacteria, boost minerals absorption, and treat constipation.

However, fiber sits in your gut and helps you eat fewer calories by promoting a feeling of fullness.

In one study, 176 individuals who consumed glucomannan fiber and followed a healthy lifestyle lost 8–10 pounds within 5 weeks. This means a fiber-rich diet is an essential element of weight loss, with tons of other health benefits (9).

8. Raspberry ketones

Raspberry ketone is an ingredient responsible for the special smell of raspberries. It is extracted from red raspberries, which are assumed to aid in weight loss.

A synthetic version of raspberry ketones is available and sold as a weight-loss supplement. One animal study shows that raspberry ketone may boost metabolism, suppress appetite, and boost fat burning.

Another animal study suggests that the antioxidant capacity of raspberry ketone in combination with a calorie-restricted diet can effectively prevent neurodegenerative changes caused by obesity and may delay the progression of Alzheimer’s disease in rats.

Because of the lack of evidence, it is hard to draw a conclusion about the effects of raspberry ketone on weight loss. There is no human study on raspberry ketone available (10, 11).

9. Meratrim dietary pills

Meratrim pills contain two herbal extracts, Sphaeranthus indicus and Garcinia mangostana, which may alter the fat cell metabolism. Sphaeranthus indicus is a plant related to the Asteraceae family.

It has medicinal uses in Southeast Asian countries. Likewise, Garcinia mangostana is used in the same Ayurvedic practice. These herbs are used to treat a wide range of inflammatory conditions, including diabetes, psoriasis, weight loss, and many more.

However, only one study on meratrim has been carried out. They conducted the study on 100 people, split into two groups. After 8 weeks, the meratrim group lost 11 pounds of weight and 4.7 inches of waistline.

They also noticed improvements in their blood sugar, cholesterol, and overall triglyceride levels. Interestingly, no side effects have been reported during the study (12).

10. CLA (conjugated linoleic acid)

Conjugated linoleic acid, or CLA, has long been a popular fat loss supplement. It is one of the most wholesome trans fats, and it is naturally available in certain fatty animal foods such as cheese, butter, and beef.

Conjugated linoleic acid may aid in the reduction of body fat deposits, reduce appetite, boost metabolism, and improve immunological function. Studies have shown that CLA has caused a weight loss of approximately 0.2 pounds per week for up to six months.

When compared to the dummy pill, CLA can help you lose about 3 pounds more. It may cause stomach discomfort, diarrhea, nausea, exhaustion, headaches, backaches, and an increased risk of bleeding if used in large doses.

Conjugated linoleic acid can also cause liver damage, however, it is very rare.


Dietary supplements for weight loss are available over-the-counter in a variety of forms. There is no conclusive evidence that weight loss supplements work.

The FDA restricts the use of medicinal compounds in dietary supplements because they may interact with other medications and pose a risk to one’s health.

People considering using weight-loss supplements should consult with their doctor about the benefits and risks.