5 Supplements for Neuropathy Complications

Neuropathy is a term that describes nerve-affecting disorders, which can cause unpleasant or painful symptoms. It can be a complication of diabetes or a common side effect of chemotherapy. However, neuropathy is a treatable with the right combination of drugs, lifestyle changes, and treatment. There are several traditional supplements which are helpful in the treatment of neuropathy.

1. Fish Oil

Because of its anti-inflammatory properties and the ability to repair nerves, fish oil supplements are effective in preventing neuropathy complications. It also helps relieve discomfort and muscle soreness. It is available in the optional form. You can take up to 5,400 mg of fish oil a day. A study explored the potential of fish oil on diabetic peripheral neuropathy [1].

The anti-inflammatory effects of fish oil help to reduce pain and discomfort. The neuroprotective effects of fish oil supplements can help stimulate the outgrowth of neurons. These results are encouraging, however, to elaborate on these findings, we need more studies.

Fish oil supplements will help you avoid neuropathy problems. It also aids in the relief of pain and muscle soreness.

2. B Vitamins

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B vitamins are useful because they promote the safe functioning of the nervous system. Vitamin B-1 (thiamine and benfotiamine), B-6, and B-12 should be included. Benfotiamine is like vitamin B-1, also known as thiamine. It is efficient in reducing pain, inflammation, and preventing nerve damage.

However, vitamin B-12 deficiency can cause permanent nerve damage if left untreated. Vitamin B-6 can help protect the nerve. But you need not take over 200 milligrams (mg) of B-6 per day. Getting higher amounts can also cause damage to the nerves and cause neuropathic symptoms [2].

Research suggests that vitamin B supplements can prevent neuropathy complications [3]. This may be because B vitamins can promote the regeneration of nerve tissue and enhance nerve function. Studies show the value of benfotiamine combined in the treatment of neuropathy complications [4], [5].

These studies show that discomfort was reduced, and the condition improved. But a small study found that people with type 1 diabetes who took 300 mg of benfotiamine a day showed no significant nerve function or decrease in inflammation [6].

B vitamins are beneficial because they help the neurological system work properly. B-1 (thiamine and benfotiamine), B-6, and B-12 vitamins should all be provided. 

3. Curcumin

Curcumin is an herb best known for its anti-inflammatory, antioxidant, and analgesic properties. It can help relieve tingling and numbness in your hands and feet. It is available in the additional forms, and you can take 1 teaspoon 3 grams of turmeric powder with 1/4 teaspoon ground pepper. You can also add turmeric to tea, curries, egg salads, and smoothies.

An animal study in mice that took turmeric supplements for 14 days decreased chemotherapy-induced neuropathy complications [7]. It had a positive impact on pain, swelling, and loss of function. The levels of antioxidants and calcium in mice improved. However, to expand on these results, we need greater human studies.

Curcumin is a plant that is well known for its anti-inflammatory, antioxidant, and analgesic qualities. It can help you get rid of tingling and numbness in your hands and feet. 

4. Alpha-Lipoic Acid

Alpha-lipoic acid (ALA) supplements can be effective in the treatment of diabetes and cancer-induced neuropathy complications. It can reduce blood sugar levels, enhance nerve function, and ease painful symptoms in the legs and arms, such as discomfort, itching, tingling, prickling, numbness, and burning [8].

You can take up to 1,200 mg per day in capsule form. Alpha-lipoic acid has a positive effect on the conduction of nerves and decreased neuropathic pain. A small study shows that alpha-lipoic acid is useful in protecting people from diabetic neuropathy and oxidative damage [9].

Supplements containing alpha-lipoic acid (ALA) have been beneficial in the treatment of diabetic and cancer-induced neuropathy problems. It can lower blood sugar levels, improve nerve function, and ease unpleasant sensations.

5. Acetyl-L-Carnitine

Acetyl-L-carnitine is an antioxidant and amino acid. It can increase energy, create healthy nerve cells, and reduce neuropathic pain. A standard dose is 500 mg twice daily. According to the study, peripheral neuropathy complications, cancer-associated fatigue, and physical conditions were improved after consuming acetyl-L-carnitine supplements [10]. Participants had 3 grams of acetyl-L-carnitine per day for 8 weeks. They observed significant differences in just 12 weeks between the groups.

Acetyl-L-carnitine can boost energy, regenerate nerve cells, and ease neuropathic pain.


We do not intend these supplements to replace any treatment plan approved by the health care providers for neuropathy complications. Such supplements may be superior to other treatment options, as they have fewer side effects. In other ways, these supplements can also support your overall well-being.

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