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Arginine (L-Arginine) Overview: What is Arginine?

Arginine (L-Arginine)

Arginine (L-Arginine) is an amino acid that is a precursor to several important metabolites, including nitric oxide. In the urea cycle, it is an important intermediate and can boost growth hormone secretion. In addition, arginine alpha-ketoglutarate (AAKG) can help in the production of nitric oxide (1).

Nitric oxide is the fresh superstar molecule that seems to play a direct or indirect role in every aspect of human physiology such as the immune system, nervous system, circulatory system, and many others. L-Arginine is the key element of the nitric oxide production pathway, vital for a cascade of vasodilatation and cardiovascular responses.

Arginine / AAKG supplements should improve NO (nitric oxide) production and boost the pump you get during a hard exercise in the gym. A recent study shows that arginine may have a legitimate health and well-being uses. For example, it is necessary to expand and contract the lining of artery walls called the endothelium.

However, several studies have discovered arginine supplements in the coronary arteries at 8-20 grams per day restored by endothelial vasodilation. It may also improve the general blood flow, which is important for individuals who are chemically affected.

Arginine supplementation can also improve erectile function in males with erectile dysfunction. Therefore, NO is crucial for proper erection and blood flu.

The Bottom Line

Arginine has a very excellent safety profile and seems to have nearly no toxic effects. From the point of view of athletic/muscle building, things get much less clear. Early studies suggested that arginine might boost growth hormone concentrations. In reality, they discovered these effects using very high doses. There was an intravenous and temporary spike in GH. Therefore, it does not have beneficial effects on muscle mass in healthy athletes.

Frequently Asked Questions

What is L-arginine?


L-arginine or arginine is one of the 22 amino acids (protein-forming nitrogen-containing molecules) which are the building blocks. In addition, it is important for growth and body tissue repair. It can also produce hormones, proteins, antibodies, neurotransmitters, and help transport substances throughout the body. However, arginine is classified as a non-essential amino acid.

Can I take too much arginine?


Arginine is least toxic of all amino acids by nutritionists and its intake, particularly in fairly enormous quantities, has very few negative side effects.

What is the recommended daily dosage of arginine?


The effects of the supplementation with arginine are dose dependent and can range from 5 to 30 grams taken orally per day.

Is it safe to take arginine with my medications?


First, someone who is taking any medications prescribed by their doctor will continue to take those medications and definitely check with your doctor before adjusting your daily routine.

Can pregnant women take arginine?


Studies show that arginine-derived nitric oxide can support a particular hypertension called preeclampsia, and can prevent premature labor and premature birth.

Is it true that arginine can cause herpes virus?


Arginine can not cause herpes outbreaks, however, when a low-grade arginine formula has been ingested may intensify virus replication during an outbreak.

Can I give arginine to my children?


About 60% of children aged 5 to 10 years already have at least one risk factor of cardiovascular diseases, such as elevated levels of cholesterol, high blood pressure or diabetes. Hydrogenated foods are harmful to humans. This can deplete the nitric oxide system which causes cardiovascular disease. However, if your child eats healthy high Arginine Foods, then there’s no need to give an arginine supplement to them.

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Naeem Durrani BSc
Naeem Durrani is a freelance journalist who specializes in health and wellness innovation. His interests include medical research, nutrition, and the scientific evidence around effective wellness practices that empower people to positively transform their lives.
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